Our present study shows that treatment of TBNC cells with the DUBs inhibitor b-AP15 causes dose-dependent caspase-3 activation and apoptosis both of which occurs well after onset of proteotoxic stress, suggesting that apoptosis mediated cells death is a consequence of unsustainable levels of UPS stress in breast cancer cells following DUBs inhibition. This evidence concerns the gene CASP3 and breast carcinoma.