MYC p19ARF−/− and MYC p53−/− mice, compared to MYC (Eμ-tTA TRE-MYC) transgenic mice, exhibited shorter latencies of tumor onset (73 versus 89 days, p = 0.002; 40 versus 89 days, p = 0.001) (Figure 1A). Here, MYC is linked to neoplasm.