A phase II clinical trial for Foretinib (also called XL880) in papillary renal cell carcinoma (pRCC) showed an overall response rate (ORR) of only 13.5% but an ORR of 50% in patients with a c-Met germ line mutation; however, c-Met amplification was found in only 3% for this tumor type [80]. The gene discussed is MET; the disease is papillary renal cell carcinoma.