Of the 349 tumors, 148 harbored T1799A mutation (p.V600E) of the BRAF gene by both Sanger sequencing and Cobas 4800 BRAF V600 Mutation Test, including 38 cases of CRC, 100 cases of PTC and 10 cases of malignant melanoma (Figure 1). The gene discussed is BRAF; the disease is melanoma.