RAB39B and infection: Electrophysiological recordings were carried out on primary murine hippocampal neurons that were infected with the shRab39b or control shScramble lentiviruses at multiplicity of infection (MOI) 1 to ensure that pre-synaptic inputs and post-synaptic outputs come from infected (silenced) neurons and after 6 days in culture transfected with a flag-RAB39B-rescue, as previously described10 (Supplementary Fig. 6c,d).