IL6 and cardiovascular disorder: In a sample from the Monitoring Trends in and Determinants in Cardiovascular Disease (MONICA) trial, despite sICAM-1 levels being independently associated with the risk of having at least one carotid or femoral plaque, no significant association was found with carotid intima–media thickness (CIMT).16 Similarly, Amar et al. showed interleukin-6 and ICAM levels were associated with stable atherosclerotic plaque but not with IMT.17