In this study, we investigated the following: 1) relationship between p-SUVmax and expression of pAkt (Ser-473), pAkt (Thr-308), and pS6 protein in the primary tumor; 2) whether the p-SUVmax predicted relapse of organ-confined or locally advanced RCC without distant metastasis (cTanyNanyM0) after radical nephrectomy; and 3) whether the p-SUVmax or m-SUVmax predicted the response of metastatic lesions (cTanyNany M1) to cytokine/immunotherapy and/or molecular targeting therapy after radical nephrectomy. Here, TAS2R63P is linked to renal cell carcinoma.