Although the metabolic function of UCP2 is still controversial and varies between various types of tissues, it is believed to have a pivotal role in obesity, diabetes, metabolic syndrome and several neurodegenerative diseases2627 Hepatic UCP2, which uncouples oxidative phosphorylation with ATP production, is highly associated with oxidative phosphorylation and fatty-acid oxidation. Here, UCP2 is linked to obesity due to melanocortin 4 receptor deficiency.