Furthermore, between days 3 and 5 of Ang II infusion, two out of six ApoE−/− mice died from aneurysm rupture, but no deaths occurred in Rgs1−/−ApoE−/− mice, indicating that Rgs1 deficiency confers protection from Ang II-induced aortic aneurysm rupture. This evidence concerns the gene RGS1 and aortic aneurysm.