In addition, when Rgs1−/− and wild-type T cells are transferred in the inflammatory colitis model in Rag2-deficient mice, wild-type mice were more susceptible to colitis, presumably through RGS1 repressing T-cell egress from the gut14 associating RGS1 in having a key role in leukocyte accumulation. Here, RGS1 is linked to colitis.