ACSL5 and colorectal carcinoma: In addition, our data showed that depletion of DHX32 in CRC cells increased expression of pro-apoptotic molecule ACSL-5 and reduced anti-apoptotic molecules Bcl-2 and CA9. Several studies show that ACSL-5 is expressed in mitochondria and its activities are associated with increased susceptibility of apoptosis and cell death pathways24, 25.