The “bait” network (Fig. 3A) contained genes such as AKT3, considered the underlying cause for the microcephaly in patients with the 1q44 microdeletion syndrome[39], and MAPK1, involved in neurogenesis[40] and located within the distal 22q11 deletion frequently associated with microcephaly[41]. The gene discussed is MAPK1; the disease is Down syndrome.