To disentangle the association of IL6R with inflammation and risk of CHD, we analyzed the association of IL6R haplotypes with circulating levels of inflammatory biomarkers [CRP, fibrinogen, sIL6R, IL6, interleukin 8 (IL8) and TNF-α] and with the risk of myocardial infarction (MI) and CHD. The gene discussed is TNF; the disease is myocardial infarction.