In addition, although some of the antigens very specific to BC have been purified up until to now, they are not detectable in most of the sera from women in early stages of BC (i. e., AutoAntibodies (AAb) to NYESO1 are found in 4%, SCP1in 6%, and SSX2 in only 1% of sera from breast cancer patients) [14]. This evidence concerns the gene SSX2 and breast cancer.