EYA4 and cardiomyopathy: However, the shorter E193 (causing the deletion of a 4846-bp region that includes the last nucleotide of exon 9, intron 9, exon 10, and part of intron 10) caused NSHL and cardiomyopathy because these mutated proteins did not bind SIX proteins and could not dimerize with full-length EYA4 [9].