In myeloma cells, we have previously reported that following IL-6 stimulation, both CD45RO and CD45RB, but not CD45RA, translocated to lipid rafts from outside of raft compartments, where they formed a complex with Lyn and activated Lyn by dephosphorylating Lyn Tyr 507 at the carboxy terminal and phosphorylating Lyn Tyr 396 [17]. Here, IL6 is linked to plasma cell myeloma.