Compared to females, male subjects were older, and they had higher BMI, larger WC, higher systolic and diastolic BP, higher levels of fasting glucose, LDL, TG, ALT, AST, and GGT, but lower platelet counts, serum cholesterol, and HDL levels (S1 Table). Moreover, male subjects had a significantly higher rate of fatty liver diagnosed by ultrasonography (54.1% vs. 33.2%, p< 0.001) and higher FLI (mean ± standard deviation, 35.35 ± 24.68 vs. 17.70 ± 19.70, p< 0.001) than female subjects. The gene discussed is GPT; the disease is fatty liver disease.