Evaluations of markers for the unfolded protein response (UPR) showed that phosphorylated elF2a and its transcriptional target CHOP were induced in all of these GIST lines by 2DG, whereas IRE1a levels were induced in GIST48B but not in GIST-T1 and GIST430. This evidence concerns the gene ERN1 and gastrointestinal stromal tumor.