In agreement with this prediction, using the Rembrandt database (Madhavan et al., 2009) we found that all four top-ranked Klf7-mediated drivers attain significant effects on survival of patients with glioblastoma (Kaplan–Meier p < 1 × 10−11, 1.4 × 10−4, 1 × 10−4 and 0.01 for the four drivers Ntng2, p35, Rexo2 and Lrrk2, respectively; in all cases, FDR < 0.05, Figure 3—figure supplement 1C), supporting the role of module no. 2 in cell invasiveness. This evidence concerns the gene REXO2 and glioblastoma.