CLCA1 (Yang et al., 2013), CLCA2 (Sasaki et al., 2012; Walia et al., 2012), and CLCA4 (Yu et al., 2013) have all been implicated in various cancers as have a number of TMEM16 proteins (West et al., 2004; Dutertre et al., 2010; Duvvuri et al., 2012; Liu et al., 2012; Qu et al., 2014), and such studies could have tremendous implications for cooperative CLCA/TMEM16 roles in cancer and other diseases. This evidence concerns the gene CLCA4 and cancer.