Indeed, accumulating evidence have demonstrated that IL-13, is significantly involved in development of AHR [44,56,57], and in the modulation of various pathophysiological aspects of asthma, such as class switching to IgE, mucus production, inflammation, airway remodeling and the contraction of airway smooth muscle (ASM) through an interaction with specific receptors on the cell surface [58]. The gene discussed is IGHE; the disease is asthma.