The immunomodulatory effects produced by the plant extract, as well as warifteine include inhibition the proliferation of splenocytes and increased IL-10 production [7], inhibition of production of ovalbumin (OVA) -specific IgE [8] and inhibition of anaphylactic shock induced by OVA [9]; inhibition of recruitment and activation of eosinophils in vivo, associated with reduced production of eotaxin and CysLTs [10]; inhibition of mast cell activation in vitro [11], in addition to modulation of AHR and of airway remodeling in experimental asthma model [12]. The gene discussed is IGHE; the disease is asthma.