FOXC2 and cancer: Second, the induction of epithelial-to-mesenchymal transition (EMT) of the cancer cells after peptide treatment is validated as well: both the Forkhead box protein C2 (FOXC2) and Tyrosine-protein kinase (Axl) expression are significantly induced [29, 30]; an increase in Vimentin expression, together with a decrease in E-cadherin are associated with EMT as well, leading to tumour cell migration and cancer metastasis [31].