In terms of PRDXs expression in spermatozoa, the population of infertile men is heterogeneous; sperm PRDX6 was low in 67% and 39% varicocele and idiopathic infertile patients, respectively, whereas sperm PRDX1 was only low in 42% of varicocele patients [43]. The gene discussed is PRDX6; the disease is varicocele.