Hence, these various points may explain why negative results were observed in our series and, in particular, why the RHOXF2 SNPs did not appear to predispose their bearers to infertility.Due to technical limitations and the very high degree of homology between RHOXF2 and RHOXF2B, we could not distinguish between RHOXF2 or RHOXF2B polymorphisms. The gene discussed is RHOXF2B; the disease is Infertility.