SHANK3 and schizophrenia: Some of the mutations of the genes related to ASD, including NRXN1, NRXN2, NLGN2, NLGN4, SHANK3, and SynGAP, have been also found in the schizophrenia patients [10-13]; for instance, two de novo mutations (R1117X and R536W) were identified in the SHANK3 gene of two families of schizophrenia [13].