As shown in Table I, specific IgE against at least one subtype of SEs was detected in the serum from 9 of 30 (30.0%) subjects with CRSsNP, 13 of 40 (32.5%) with CRSwNP and 2 of 30 (6.7%) controls, respectively (level range, grades I-III). The gene discussed is IGHE; the disease is chronic rhinosinusitis without nasal polyps.