Yung et al demonstrated that the activation of AMPK induced by 25 mM metformin caused the upregulation of p-AMPK expression and the downregulation of p-Akt expression, and the phosphorylation of FOXO3a and Forkhead Box M1 (FOXM1) in cervical cancer cell line C33A. The gene discussed is FOXM1; the disease is cervical carcinoma.