The study also revealed that following the inhibition of FOXO3a by siRNA, the expression of FOXM1 was not significantly altered by metformin, which indicated that metformin may have suppressed cervical cancer cell growth through activation of the AMPK and inhibition of the Akt/FOXO3a/FOXM1 signaling pathways (15). This evidence concerns the gene FOXO3 and cervical carcinoma.