CD4 and Cowden disease: As regards the 63 patients who underwent immunoglobulin and the 101 who underwent CD series tests, the IgG, IgA and IgM results were all normal, 1 patient exhibited decreased IgA and 71% of the patients had CD series count abnormalities, with the majority expressing decreased CD4+ and CD8+ and some patients expressing increased CD19+ (Table I).