The phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling pathways are the two major pro-proliferative and anti-apoptotic pathways; by affecting the activation of downstream apoptosis-related proteins and cell cycle regulatory proteins, they play important roles in tumor cell proliferation, angiogenesis and metastasis as well as in antagonistic chemotherapy. This evidence concerns the gene AKT1 and neoplasm.