However, overexpression of Sema5A in pancreatic cancer has been shown to correlate with invasion, metastasis and increased endothelial cell proliferation (28,29), while overexpression of Sema5A and plexin-B3 are associated with the invasion and metastasis of gastric carcinoma (20). This evidence concerns the gene PLXNB3 and familial pancreatic carcinoma.