The objective of the present study, therefore, was to transduce human MSCs from umbilical cord (hUMSCs) with Lenti-IL-18 recombinant virus and observe the antitumor effect, in order to determine whether hUMSCs modified with IL-18 gene could suppress the proliferation, invasion and migration of breast cancer cells in vitro. The gene discussed is IL18; the disease is breast cancer.