H2BC5 and Behcet disease: In the field of histone modifications, most of the studies have been related to SCZ and BD providing strong evidence for aberrant expression of several genes of histone proteins, including HIST1H2BC, HIST1H2BD, HIST1H2BH, HIST1H2BG, HIST1H4K and HIST2H2BE) in the blood cells of these patients and/or their first degree relatives (41, 42).