GRM5 and autism: Although the development of next generation sequencing technology (the most advanced method for the detection of unknown mutations in whole exome/genome analysis) could help to identify a number of new candidate genes for SCZ (e.g. GRM5, PPEF2 and LRP1B), and autism (e.g. SCN2A), it has yet to introduce any gene(s) with a key role in major mental diseases (15-21).