In a previous report, the probiotic E. coli Nissle 1917 led to restoration of a disrupted epithelial barrier of T84 cell monolayer caused by pathogenic E. coli infection, which was associated with increased expression and relocalization of zonula occludens-2 (ZO-2) (Zyrek et al. The gene discussed is TJP2; the disease is escherichia coli infection.