It has been previously demonstrated that the TP63/TP53L, ERG, GRHL1/Get-, HNF1A/TCF-1, SPI1/PU.1, WT1 and GLIS2, FOXM1 and FOXP3 transcription factor networks, which are mediated by HNF4A, can regulate the expression of Trop2 in tumor tissues (14). The gene discussed is GRHL1; the disease is neoplasm.