We found that pathways of apoptosis, antigen processing and natural killer cells mediated cytotoxicity were all significantly down-regulated (all P < 0.001), associated with high expression of ITPR2. This result, just being consistent to previously presented dysregulated genes, possibly illustrated why high expression of ITPR2 was associated with adverse outcome in CN-AML. This evidence concerns the gene ITPR2 and acute myeloid leukemia.