ITPR2 and acute myeloid leukemia: Of these microRNAs, miR-155 and two members of miR-181 family(miR-181-a-1 and miR-181c) were positively associated with ITPR2 expression, the former of which has been validated to predict worse outcome for CN-AML patients [14], and the latter were recently shown to be potential targets and associated with adverse outcomes for AML patients [25].