Based on promising preclinical evidence on the relationship between Src and solid cancers, including HNSCC [46, 47], inhibitors such as dasatinib (BMS- 354825, SPRYCEL®, Bristol-Myers Squibb), bosutinib (SKI-606, Wyeth/Pfizer) and saracatinib (AZD0530, AstraZeneca) have been developed and are currently being used in clinical trials [6, 48]. This evidence concerns the gene SRC and head and neck squamous cell carcinoma.