HSPA5 and hepatocellular carcinoma: In our previous study, certain proteins such as p62, c-Myc, p53, cyclin B1, survivin, p16, RalA, Koc, IMP-1, Sui1, HCC1, GRP78 and p90, were evaluated and validated as TAAs in HCC, and autoantibodies against these TAAs have been detected in sera from patients with HCC (34,35).