In our previous study, certain proteins such as p62, c-Myc, p53, cyclin B1, survivin, p16, RalA, Koc, IMP-1, Sui1, HCC1, GRP78 and p90, were evaluated and validated as TAAs in HCC, and autoantibodies against these TAAs have been detected in sera from patients with HCC (34,35). The gene discussed is CCNB1; the disease is hepatocellular carcinoma.