After replication of top hits in an independent SSc case–control study, this study identified novel SSc associations at KIAA0319L and the previously described SLE susceptibility loci PXK and JAZF1. An additional GWA follow-up study identified a genomewide significant association of SSc with polymorphism near PPAR-γ [52], a gene implicated in metabolism, immunity, and protection from fibrosis [53]. The gene discussed is PPARG; the disease is systemic sclerosis.