The T47D cells under co-culture responded to macrophage signals by up-regulating S100A8, S100A9, TGM2, TGM3, CFSR3, WNT5A, ICAM, MRAS, ID1 and CCL2, which are all known mediators of tumor progression (Fig. 3c). The gene discussed is TGM2; the disease is neoplasm.