This is in remarkable agreement with the diffuse, selective expression of TGF-β1 in ZG (and zona reticularis but not ZF) of human adrenal and its potent inhibition of basal, ACTH-, cAMP-, potassium-, and angiotensin II–stimulated aldosterone secretion.27,31,32 Although our study is in apparent disagreement with that seen in breast cancer, both studies found DACH1 to repress AP-1 activity (Figure S6A). The gene discussed is POMC; the disease is breast cancer.