E-cadherin, the cellular adhesion molecule that forms the cell–cell adhesion junctions of epithelial cells, is essential for the cells to maintain their epithelial phenotype.12 During the onset of EMT, E-cadherin is cleaved at the plasma membrane and subsequently degraded, resulting in loss of epithelial adherent junctions.13 Thus, downregulation or loss of E-cadherin expression is considered to be the hallmark event of EMT.3, 6, 13 In support of this mechanism, increase in E-cadherin expression will effectively increase cell–cell adhesion and reduce cell motility in tumour cells. Here, CDH1 is linked to neoplasm.