DACH1 and neoplasm: DACH1 has been implicated in the suppression of tumour metastasis by binding to a subset of genes and repressing their expression.28 A previous report has demonstrated that DACH1 inhibits cellular migration and invasion of breast cancer by binding to and repressing the IL-8 gene.38 Recently, DACH1 has also been shown to inhibit EMT through repression of the cytoplasmic translation of SNAI1 by inactivating the Y box-binding protein (YB-1).40 Inactivation of YB-1 also results in suppression of the YB-1-mediated gene expression that governs cell invasion.