CDH1 and neoplasm: They may acquire a migratory behaviour, allowing them to move away from their microenvironment and into surrounding or remote locations.8, 9 Sometimes, cells that undergo EMT can transiently re-acquire an epithelioid phenotype by reverse mesenchymal–epithelial transition.10, 11, 12 In most epithelial cancers, loss of E-cadherin gene or protein expression is frequently found in tumour cells that undergo EMT.