NHERF1 and anaplastic ependymoma: To determine whether NHERF1 can be used as a diagnostic marker of ependymal tumors, a multi-institutional effort assembled a total of 113 primary brain tumors consisting of ependymomas, anaplastic ependymomas, and lower grade ependymal tumors, as well as miscellaneous other tumors considered in the differential diagnosis (Table 1).