NHERF1 and brain neoplasm: To investigate the composition of NHERF1 protein complexes in ependymoma, we screened the intracellular localization of the NHERF1 ligands moesin, NF2, PTEN, PDGFRα, EGFR, YAP1, β-catenin and PHLPP2 that have been functionally involved in primary brain tumors [11,22-27] (Figure 3A).