Since AKT/mTOR is downstream of CXCR4 and is involved in the SDF-1/CXCR4 signaling pathway, we hypothesized that IL-24 regulates cell migration and invasion by disrupting the SDF-1/CXCR4 axis in NSCLC. The gene discussed is CXCR4; the disease is non-small cell lung carcinoma.