This is reflected by the genetics of corticotropin independent Cushing syndrome with adrenal hyperplasia (OMIM: #610489; #219080), which is observed in association with Carney complex (OMIM: #160980) as well as McCune-Albright syndrome (polyostotic fibrous dysplasia) (OMIM: #174800). The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.