Nevertheless, CB1 and TRPV1 seem to keep a close biological influence between each other because we have detected a significant increase of CB1 immunoreactivity in the inner 1/3 ML and an increase of DAGL-α and NAPE-PLD optical densities in dentate gyrus of TRPV1-KO versus WT (unpublished observations) which may have a functional benefit in certain pathological conditions, such as epilepsy. The gene discussed is TRPV1; the disease is epilepsy.