DDIT3 and diffuse large B-cell lymphoma: As many clinicians treat DLBCL-RS with R-CHOP outside of a clinical trial, the National Cancer Research Institute (NCRI) UK-based “CHOP-OR” single arm, multicentre study was therefore designed to investigate whether DLBCL-RS treated with six cycles of CHOP-O followed by maintenance ofatumumab every eight weeks for 48 weeks in responding patients was feasible and improved clinical efficacy over and above R-CHOP.