Consequently, pretreatment with fingolimod-phosphate significantly decreased the protein levels of the p65 subunit of NFκB in the BMECs, which were upregulated after exposure to the sera from the RRMS-R, RRMS-S and SPMS patients, compared to that without treatment with fingolimod-phosphate (Fig. 3A-B). The gene discussed is NFKB1; the disease is secondary progressive multiple sclerosis.