For this experiment live rat hippocampal neurons were incubated for 24 hours with GAD65 antibodies contained in the CSF of four patients with cerebellar ataxia, four with SPS, three with LE and five with epilepsy; the same experiment using CSF with NMDAR antibodies from a patient with anti-NMDA receptor encephalitis served as control of IgG internalization. This evidence concerns the gene GAD2 and epilepsy.