PTX3 and pulmonary fibrosis: To determine if PTX3 is associated with human lung fibrosis, we examined the distribution of PTX3 in lung tissue from chronic obstructive pulmonary disease (COPD) patients with relatively normal lungs (> 80% FVC) and idiopathic pulmonary fibrosis (IPF) patients (<50% FVC) (Table 1) (Fig. 10).