TNFRSF8 and cancer: In further investigation of the function for the negatively related genes, the hypermethylated genes were mainly enriched in cancer-related pathways, including Systemic lupus erythematosus(CD40), Cytokine-cytokine receptor interaction(TNFRSF8, CX3CL1, CD40, IL11RA, ACVR1), Neuroactive ligand-receptor interaction(MCHR2, PPYR1, GRIA2) and autoimmune thyroid disease(CD40).