In addition to BRG1 and BRM, functional redundancy may exist among other subunits (e.g., BAF60A, BAF60B, and BAF60C; or BAF155 and BAF170; or ARID1A and ARID1B), which suggests a mechanism by which the SWI/SNF complex may be further protected from cancer-driven subunit loss (2, 25). Here, SMARCA1 is linked to cancer.