Similarly PBRM1 was found to be infrequently silenced by mutations in human cancer cell lines (96); in contrast, PBRM1 has been found to be silenced in 3.6–7% of stomach, endometrial, melanoma, pancreatic, cervical, bladder, and head/neck cancers based on the TCGA database. Here, PBRM1 is linked to melanoma.